Publications
Articles
2022
Boosting the sensitivity of paper-based biosensors with polymeric water-soluble reservoirs
María del Mar González del Campo, Alejandra Alba-Patiño, Carlos Palomino, Marta Bauzá, Estrella Rojo Molinero, Antonio Oliver, Gemma Turnes, Roberto de la Rica. Sensors and Actuators B 2022, 354, 131214
https://www.sciencedirect.com/science/article/pii/S0925400521017822?dgcid=author
Dissolvable Polymer Valves for Sweat Chrono-Sampling in Wearable Paper-Based Analytical Devices
Andreu Vaquer, Enrique Barón, and Roberto de la Rica. ACS Sensors 2022 7, 2, 488–494.
https://pubs.acs.org/doi/full/10.1021/acssensors.1c02244
Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care
Alejandra Alba-Patiño, Andreu Vaquer, Enrique Barón, Steven M. Russell, Marcio Borges & Roberto de la Rica. Microchimica Acta 2022, 189, 74
https://link.springer.com/article/10.1007/s00604-022-05171-2
Improving the Quantification of Colorimetric Signals in Paper-Based Immunosensors with an Open-Source Reader
Steven M. Russell, Alejandra Alba-Patiño, Andreu Vaquer, Antonio Clemente and Roberto de la Rica. Sensors 2022 22(5), 1880; https://doi.org/10.3390/s22051880
https://www.mdpi.com/1424-8220/22/5/1880
Polymer Components for Paper-Based Analytical Devices
María del Mar González del Campo, Andreu Vaquer, Roberto de la Rica. Advanced Material Technologies 2022, 2200140.
https://onlinelibrary.wiley.com/doi/10.1002/admt.202200140
Rapid Identification and Classification of Pathogens That Produce Carbapenemases and Cephalosporinases with a Colorimetric Paper- Based Multisensor
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noé,
and Roberto de la Rica. Analytical Chemistry 2022, 94, 9442−9449.
https://doi.org/10.1021/acs.analchem.2c01724
Plasma-induced nanoparticle aggregation for stratifying COVID-19 patients according to disease severity
Giulia Santopolo, Antonio Clemente, Marta González-Freire, Steven M. Russell, Andreu Vaquer, Enrique Barón María Aranda, Antonia Socias, Alberto del Castillo, Marcio Borgesa, Roberto de la Rica. Sensors and Actuators B: Chemical
2022, 373, 132638.
https://www.sciencedirect.com/science/article/pii/S0925400522012813?dgcid=author
2021
Bedside Detection of Carbapenemase-Producing Pathogens with Plasmonic Nanosensors
Giulia Santopolo, Estrella Rojo-Molinero, Antonio Clemente, Marcio Borges, Antonio Oliver,Roberto de la Rica. Sensors and Actuators B-Chemical 2021, 329, 129059
https://www.sciencedirect.com/science/article/abs/pii/S0925400520314064
Wearable Analytical Platform with Enzyme-Modulated Dynamic Range for the Simultaneous Colorimetric Detection of Sweat Volume and Sweat Biomarkers
Andreu Vaquer, Enrique Barón, Roberto de la Rica. ACS Sensors 2021, 6, 130–136.
https://pubs.acs.org/doi/10.1021/acssensors.0c01980
Paper biosensors for detecting elevated IL-6 levels in blood and respiratory samples from COVID-19 patients
Cristina Adrover-Jaume, AlejandraAlba-Patiño, Antonio Clemente. Giulia Santopolo, Andreu Vaquer, Steven M.Russell, Enrique Barón, María del Mar González del Campo, Joana M.Ferrer, María Berman-Riu, Mercedes García-Gasalla, María Aranda, Marcio Borges, Roberto de la Rica. Sensors and Actuators B, Chemical 2021, 330, 129333.
https://www.sciencedirect.com/science/article/pii/S0925400520316737
Immunodetection of Lung IgG and IgM Antibodies against SARS-CoV-2 via Enzymatic Liquefaction of Respiratory Samples from COVID-19 Patients
Antonio Clemente, Alejandra Alba-Patiño, Giulia Santopolo, Estrella Rojo-Molinero, Antonio Oliver, Marcio Borges, María Aranda, Alberto del Castillo, Roberto de la Rica. Analytical Chemistry 2021, 93, 12, 5259–5266.
https://pubs.acs.org/doi/10.1021/acs.analchem.1c00251
Detection of low glucose levels in sweat with colorimetric wearable biosensors
Andreu Vaquer, Enrique Barón, Roberto de la Rica. Analyst 2021,146, 3273-3279
https://pubs.rsc.org/en/Content/ArticleLanding/2021/AN/D1AN00283J#!divAbstract
Nanoparticle transfer biosensors for the non-invasive detection of SARS-CoV-2 antigens trapped in surgical face masks
Andreu Vaquer, Alejandra Alba-Patiño, CristinaAdrover-Jaume, Steven M. Russell, María Aranda, Marcio Borges, Joana Mena, Alberto del Castillo, Antonia Socias, Luisa Martín, María Magdalena Arellano, Miguel Agudo, Marta Gonzalez-Freire, Manuela Besalduch, Antonio Clemente, Enrique Barón, Roberto de la Rica. Sensors Actuators, B Chem., vol. 345, p. 130347, 2021
https://www.sciencedirect.com/science/article/pii/S0925400521009151
Optimized detection of lung IL-6 via enzymatic liquefaction of low respiratory tract samples: application for managing ventilated patients
Antonio Clemente, Alejandra Alba-Patiño, Giulia Santopolo, Enrique Barón, Estrella Rojo-Molinero, Antonio Oliver, Jon Pérez-Bárcena, Paz Merino de Cos, María Aranda, Alberto Del Castillo, Antonia Socias, Marcio Borges, Roberto de la Rica. Analyst, 2021,146, 6537-6546
https://pubs.rsc.org/en/content/articlelanding/2021/an/d1an00763g
Colorimetric Detection of Sepsis-Derived Hyperdegranulation with Plasmonic Nanosensors
Giulia Santopolo, Antonio Clemente*, Maria Aranda, Antonia Socias, Alberto del Castillo, Aniceta Chica, Marcio Borges, and Roberto de la Rica. ACS Sensors 2021, 6, 12, 4443–4450.
https://pubs.acs.org/doi/abs/10.1021/acssensors.1c01884
2020
Nanoparticle Reservoirs for Paper-Only Immunosensors
Alejandra Alba-Patiño, Cristina Adrover-Jaume, Roberto de la Rica, ACS Sensors 2020, 5, 147−153. Published as "Editor´s choice".
https://pubs.acs.org/doi/pdf/10.1021/acssensors.9b01937
Nanoparticle-Based Mobile Biosensors for the Rapid Detection of Sepsis Biomarkers in Whole Blood
A. Alba-Patiño, S. M. Russell, M. Borges, N. Pazos-Pérez, R. A. Álvarez-Puebla, R. de la Rica. Nanoscale Advances 2020, 2, 1253-1260.
https://pubs.rsc.org/en/content/articlepdf/2020/na/d0na00026d
Iron Assisted Synthesis of Highly Monodisperse and Magnetic Citrate-stabilized Small Silver Nanoparticles
Maria Blanco-Formoso, Mariacristina Turino, Beatriz Rivas-Murias, Luca Guerrini, Alexey Shavel, Roberto de la Rica, Miguel A. A. Correa-Duarte, Verónica Salgueiriño, Nicolas Pazos-Perez, Ramon A. Alvarez-Puebla. Journal of Physical Chemistry C 2020, 124, 5, 3270–3276.
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcc.9b10606
Biosensors for Managing the COVID-19 Cytokine Storm: Challenges Ahead
Steven M. Russell, Alejandra Alba-Patiño, Enrique Barón, Marcio Borges, Marta Gonzalez-Freire* and Roberto de la Rica.* ACS Sensors 2020, 5, 6, 1506–1513.
https://pubs.acs.org/doi/10.1021/acssensors.0c00979
Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study
Roberto de la Rica, Marcio Borges, Maria Aranda, Alberto del Castillo, Antonia Socias, Antoni Payeras, Gemma Rialp, Lorenzo Socias, Lluis Masmiquel and Marta Gonzalez-Freire. Microorganisms 2020, 8(8), 1106.
https://doi.org/10.3390/microorganisms8081106
Mobile origami immunosensors for the rapid detection of urinary tract infections
Cristina Adrover-Jaume, Estrella Rojo-Molinero, Antonio Clemente, Steven M. Russell, Javier Arranz, Antonio Oliver, Roberto de la Rica. Analyst 2020 , 145, 7916–7921.
https://pubs.rsc.org/en/content/articlepdf/2020/an/d0an01218a
COVID-19: In the Eye of the Cytokine Storm
Roberto de la Rica, Marcio Borges, Marta González-Freire. Frontiers in Inmmunology 2020, 11, 558898
https://doi.org/10.3389/fimmu.2020.558898
Rapid Detection of Pseudomonas aeruginosa Biofilms via Enzymatic Liquefaction of Respiratory Samples
Antonio Clemente, Alejandra Alba-Patiño, Estrella Rojo-Molinero, Steven M. Russell, Marcio Borges, Antonio Oliver, Roberto de la Rica. ACS Sensors 2020 5, 12, 3956–3963.
https://pubs.acs.org/doi/10.1021/acssensors.0c01618
2019
Ultrafast and Ultrasensitive Naked-Eye Detection of Urease-Positive Bacteria with Plasmonic Nanosensors
Giulia Santoplo, Antonio Doménech-Sánchez, Steven M. Russell and Roberto de la Rica. ACS Sensors 2019, 4, 961-967
https://pubs.acs.org/doi/10.1021/acssensors.9b00063
Multifunctional Motion-to-Color Janus Transducers for the Rapid Detection of Sepsis Biomarkers in Whole Blood
Steven M. Russell, Alejandra Alba-Patiño, Marcio Borges, Roberto de la Rica, Biosensors and Bioelectronics 2019, 140, 111346.
https://www.sciencedirect.com/science/article/pii/S0956566319304191?via%3Dihub
Development of Plasmonic Chitosan–Squarate Hydrogels via Bioinspired Nanoparticle Growth
E. Castellanos, B.Soberats, S. Bujosa, C. Rotger, R. de la Rica, A. Costa. Biomacromolecules 2019 (accepted)
https://pubs.acs.org/doi/10.1021/acs.biomac.9b01635
2018
Policy Considerations for Mobile Biosensors
S. M. Russell and R. de la Rica, ACS Sensors 2018, 3, 1059–1068.
https://pubs.acs.org/doi/10.1021/acssensors.8b00289
Paper Transducers to Detect Plasmon Variations in Colorimetric Nanoparticle Biosensors
S. M. Russell, R. de la Rica, Sensors and Actuators B-Chemical 2018, 270, 327-332
https://www.sciencedirect.com/science/article/pii/S0925400518309547
Plug and play anisotropy-based nanothermometers
Sebastian A. Thompson, Ignacio A. Martinez, Patricia Haro- González, Alejandro Adam, Daniel Jaque, Jana B. Nieder, and Roberto de la Rica. ACS Photonics 2018, 5, 2676–2681.
https://pubs.acs.org/doi/10.1021/acsphotonics.8b00292
Origami-enabled signal amplification for paper-based colorimetric biosensors
A. Alba-Patiño, S. M. Russell, R. de la Rica. Sensors and Actuators B-Chemical 2018, 273, 951-954.
https://www.sciencedirect.com/search?authors=de%20la%20rica&show=25&sortBy=relevance
A Robust and User-Friendly Alternative to Densitometry Using Origami Biosensors and Digital Logic
S. M. Russell, A. Alba, M. Borges, and R. de la Rica. ACS Sensors 2018, 3, 1712-1718
https://pubs.acs.org/doi/10.1021/acssensors.8b00452
Label free localization of nanoparticles in live cancer cells using spectroscopic microscopy
Graham L. C. Spicer, Luay Almassalha, Ignacio A. Martinez, Ronald Ellis, John E. Chandler, Scott Gladstein, Di Zhang, The-Quyen Nguyen, Seth Feder, Hariharan Subramanian, Roberto de la Rica, Sebastian A. Thompson and Vadim Backman. Nanoscale 2018, 10, 19125-19130.
https://pubs.rsc.org/en/content/articlehtml/2018/nr/c8nr07481j
2017
Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose
G. Rucinskaite, S. A. Thompson, S. Paterson and R. de la Rica. Nanoscale 2017, 9, 5404-5407.
http://pubs.rsc.org/en/content/articlelanding/2017/nr/c7nr00298j#!divAbstract
Gold Suprashells: Enhanced Photothermal Nanoheaters with Multiple Localized Surface Plasmon Resonances for Broadband Surface-Enhanced Raman Scattering
S. Paterson, S. A. Thompson, A. W. Wark, R. de la Rica. J. Phys. Chem. C 2017, 121, 7404-7411.
http://pubs.acs.org/doi/abs/10.1021/acs.jpcc.6b12792
Augmented Reality for Real-Time Detection and Interpretation of Colorimetric Signals Generated by Paper-Based Biosensors
Steven M. Russell, Antonio Domenech-Sánchez and Roberto de la Rica. ACS Sensors 2017, 2, 848-853
http://pubs.acs.org/doi/abs/10.1021/acssensors.7b00259
One-step fabrication of LSPR-tuneable reconfigurable assemblies of gold nanoparticles decorated with biotin-binding proteins
de la Rica, R. Nanoscale 2017, 9, 18855-18860.
http://pubs.rsc.org/en/content/articlelanding/2017/nr/c7nr07574j#!divAbstract
2016
Naked-eye detection as a universal approach to lower the limit of detection of enzyme-linked immunoassays
O'Connor, E.F.; Paterson, S.; de la Rica, R. Analytical and Bioanalytical chemistry Vol 3389, pp 3389 (2016)
Self-Assembly of Gold Supraparticles with Crystallographically Aligned and Strongly Coupled Nanoparticle Building Blocks for SERS and Photothermal Therapy
S. Paterson, S. A. Thompson, J. Gracie, A. W. Wark, and R. de la Rica. Chemical Science 2016, 7, 6232-6237
http://pubs.rsc.org/en/content/articlelanding/2016/sc/c6sc02465c#!divAbstract
Light-Triggered Inactivation of Enzymes with Photothermal Nanoheaters
S. A. Thompson, S. Paterson, M. M. M. Azab, Alastair W. Wark and Roberto de la Rica, Small 2016, 13, 1603195
https://onlinelibrary.wiley.com/doi/epdf/10.1002/smll.201603195
2015
Photoluminescent nanosensors for intracellular detection
Kerr, C. A.; de la Rica, R. Analytical Metods Vol 7, pp 7067-7075 (2015)
http://pubs.rsc.org/en/content/articlelanding/2015/ay/c5ay00489f#!divAbstract
Solution-based nanosensors for in-field detection with the naked eye
Paterson, S.; de la Rica, R. Analyst (2015) Vol 140, pp 3308-3317
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AN/c4an02297a#!divAbstract
Designing Fluorescent Peptide Sensors with Dual Specificity for the Detection of HIV‑1 Protease
Herpoldt, K. L.; Artzy-Schnirman, A.; Christofferson, A.J.; Makarucha, A. J.; de la Rica, R.; Yarovsky, I.; Stevens. M. M. Chemistry of Materials (2015) (accepted)
2014
Nanoparticle Growth via Concentration Gradients Generated by Enzyme Nanopatterns
de la Rica R.; Bat, E.; Herpoldt, K. L.; Xie, H.; Bertazzo, S.; Maynard, H.D.; Stevens M. M. Advanced Functional Materials Vol 24, pp 3692–3698 (2014)
http://onlinelibrary.wiley.com/doi/10.1002/adfm.201304047/abstract
Plasmonic ELISA for the detection of gp120 at ultralow concentrations with the naked eye
Cecchin, D.; de la Rica, R.; Bain, R. E. S.; M. W. Finnis; Stevens M. M.; Battaglia,G. Nanoscale Vol 6, pp 9559-9562 (2014)
http://pubs.rsc.org/en/content/articlelanding/2014/nr/c3nr06167a#!divAbstract
Self-Assembly of Collagen Building Blocks Guided by Electric Fields
de la Rica, R; Mendoza, E.; Chow, L. W.; Cloyd, K. L.; Bertazzo, S.; Watkins, H. C.; Steele J. M. A.; Stevens, M. M. Small (In press) DOI: 10.1002/smll.201400424
http://onlinelibrary.wiley.com/doi/10.1002/smll.201400424/abstract
A designer peptide as a template for growing Au nanoclusters
de la Rica, R; Chow, L. W.; Horejs, C. M.; Mazo, M.; Chiappini, C.; Pashuck, E. T.; Bitton R.; Stevens, M. M. Chemical Communications Vol. 50, pp 10648-10650 (2014)
http://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc03240c#!divAbstract
2013
Plasmonic ELISA for the detection of analytes at ultralow concentrations with the naked eye
de La Rica Roberto, Stevens Molly M., Nature Protocols Vol 8, pp. 1759-1764 (2013
http://dx.doi.org/10.1038/nprot.2013.085
2012
Plasmonic ELISA for the ultrasensitive detection of disease biomarkers with the naked eye
de La Rica Roberto, Stevens Molly M., Nature Nanotechnology Vol 7, No. 12, pp. 821–824 (2012)
http://dx.doi.org/10.1038/nnano.2012.186
Plasmonic nanosensors with inverse sensitivity by means of enzyme-guided crystal growth
de La Rica Roberto, Rodriguez-Lorenzo Laura, Alvarez-Puebla Ramon, Liz-Marzan Luis, Stevens Molly, Nature Materials Vol 11, pp. 604–607 (2012)
http://dx.doi.org/10.1038/nmat3337
Enzyme-responsive nanoparticles for drug release and diagnostics
de La Rica Roberto, Aili Daniel, Stevens Molly, Advanced Drug Delivery Reviews Vol 64, No. 11, pp. 967-978 (2012)
http://dx.doi.org/10.1016/j.addr.2012.01.002
2011
Electrical readout of protein microarrays on regular glass slides
Bonilla Diana, Mallen Maria, de La Rica Roberto, Fernandez-Sanchez Cesar, Baldi Antoni, Analytical Chemistry Vol 83, No. 5, pp. 1726–1731 (2011)
http://dx.doi.org/10.1021/ac102938z
Biomimetic crystallization of Ag2S nanoclusters in nanopore assemblies
de La Rica Roberto, Velders Aldrik, Journal of the American Chemical Society Vol 133, No. 9, pp. 2875–2877 (2011)
http://dx.doi.org/10.1021/ja110272g
Assemblies of functional peptides and their applications in building blocks for biosensors
de La Rica Roberto, Pejoux Christophe, Matsui Hiroshi, Advanced Functional Materials Vol 21, No. 6, pp. 1018-1026 (2011)
http://dx.doi.org/10.1002/adfm.201001419
Multivalent nanoparticle networks as ultrasensitive enzyme sensors
de La Rica Roberto, Fratila Raluca, Szarpak Anna, Huskens Jurriaan, Velders Aldrik, Angewandte Chemie International Edition Vol 50, No. 25, pp. 5704–5707 (2011)
http://dx.doi.org/10.1002/anie.201008189
Supramolecular Au nanoparticle assemblies as optical probes for enzyme-linked immunoassays
de La Rica Roberto, Velders Aldrik, Small Vol 7, No. 1, pp. 66–69 (2011)
http://dx.doi.org/10.1002/smll.201001340
2010
Applications of peptide and protein-based materials in bionanotechnology
de La Rica Roberto, Matsui Hiroshi, Chemical Society Reviews Vol 39, pp. 3499-3509 (2010)
http://dx.doi.org/10.1039/B917574C
Bioinspired target-specific crystallization on peptide nanotubes for ultrasensitive Pb Ion detection
de La Rica Roberto, Mendoza Ernest, Matsui Hiroshi, Small Vol 6, No. 16, pp. 1753–1756 (2010)
http://dx.doi.org/10.1002/smll.201000489
Biomimetic crystallization nanolithography : simultaneous nanopatterning and crystallization
de La Rica Roberto, Fabijanic Kristina, Baldi Antoni, Matsui Hiroshi, Angewandte Chemie International Edition Vol 49, No. 8, pp. 1447–1450 (2010)
http://dx.doi.org/10.1002/anie.200906200
Device for electrically reading microarrays, has base having support for positioning test surface of microarray parallel to reading surface of base, and matrix of transducers arranged on reading surface of base (Patent)
Baldi Antonio, Bonilla Diana, de La Rica Roberto, Fernandez-Sanchez Cesar, (2010)
http://strathprints.strath.ac.uk/45879/
2009
Label-free cancer cell detection with impedimetric transducers
de La Rica Roberto, Thompson Sebastian, Baldi Antoni, Fernandez-Sanchez Cesar, Drain Charles Michael, Matsui Hiroshi, Analytical Chemistry Vol 81, No. 24, pp. 10167–10171 (2009)
http://dx.doi.org/10.1021/ac9021049
Single-cell pathogen detection with a reverse-phase immunoassay on impedimetric transducers
de La Rica Roberto, Baldi Antoni, Fernandez-Sanchez Cesar, Matsui Hiroshi, Analytical Chemistry Vol 81, No. 18, pp. 7732-7736 (2009)
Biomimetic conformation-specific assembly of proteins at artificial binding sites nanopatterned on silicon
de La Rica Roberto, Matsui Hiroshi, Journal of the American Chemical Society Vol 131, No. 40, pp. 14180–14181 (2009)
http://dx.doi.org/10.1021/ja905932e
Selective detection of live pathogens via surface-confined electric field perturbation on interdigitated silicon transducers
de La Rica Roberto, Baldi Antonio, Fernandez-Sanchez Cesar, Matsui Hiroshi, Analytical Chemistry Vol 81, No. 10, pp. 3830-3835 (2009)
http://dx.doi.org/10.1021/ac9001854
Self-assembled peptide nanotubes for electronics and sensor devices (Conference)
Bai Hanying, Matsui Hiroshi, de La Rica Roberto, The 237th ACS National Meeting (2009)
http://strathprints.strath.ac.uk/45765/
2008
Label-free pathogen detection with sensor chips assembled from peptide nanotubes
de La Rica Roberto, Mendoza Ernest, Lechuga Laura, Matsui Hiroshi, Angewandte Chemie. International edition in English Vol 47, No. 50, pp. 9752–9755 (2008)
http://dx.doi.org/10.1002/anie.200804299
Silane nanopatterns via gas-phase soft lithography
de La Rica Roberto, Baldi Antonio, Mendoza Ernest, San Paulo Alvaro, Llobera Andreu, Fernandez-Sanchez Cesar, Small Vol 4, No. 8, pp. 1076-1079 (2008)
http://dx.doi.org/10.1002/smll.200701038
Urease as a nanoreactor for growing crystalline ZnO nanoshells at room temperature
de La Rica Roberto, Matsui Hiroshi, Angewandte Chemie. International edition in English Vol 47, No. 29, pp. 5415–5417 (2008)
http://dx.doi.org/10.1002/anie.200801181
Spermine-induced hybridization and charge inversion at the diffuse layer of a DNA-FET
de La Rica Roberto, Fernandez-Sanchez Cesar, Cecilia Jimenez-Jorquera, Baldi Antonio, Journal of Physical Chemistry B Vol 112, No. 25, pp. 7614-7617 (2008)
http://dx.doi.org/10.1021/jp711348m
2007
Local detection of enzymatic ion generation with polycrystalline silicon interdigitated electrodes and its application to biosensing
de La Rica Roberto, Baldi Antonio, Fernandez-Sanchez Cesar, Applied Physics Letters Vol 90, (2007)
http://dx.doi.org/10.1063/1.2472718
Electric preconcentration and detection of latex beads with interdigitated electrodes
de La Rica Roberto, Fernandez-Sanchez Cesar, Baldi Antonio, Applied Physics Letters Vol 90, No. 17, (2007)
http://dx.doi.org/10.1063/1.2731311
2006
Polysilicon interdigitated electrodes as impedimetric sensors
de La Rica Roberto, Fernandez-Sanchez Cesar, Baldi Antonio, Electrochemistry Communications Vol 8, No. 8, pp. 1239-1244 (2006)