Biosensors for improving sepsis diagnosis and management

Unattend infections can progress to systemic inflammation and organ dysfunction also known as sepsis. Sepsis is a critical condition that requires immediate action in order to avoid death or long-term sequelae.

We are developing biosensors for the rapid detection of sepsis biomarkers in the emergency room. These devices are easy to use and provide results in less than 10 minutes. Thanks to this technology, septic patients will be rapidly identified during triage. In turn, this will reduce the time required to provide intravenous antibiotic treatment, which is crucial to improve outcomes.

We are also developing rapid tests to identify the pathogen causing the infections as well as key mechanisms of antimicrobial resistance. Due to the rapid expansion of antibiotic resistance the antimicrobial treatment may be ineffective even when provided in a timely manner. With our tests clinicians will be able to detect pathogens in less than 10 min so that they can personalize antibiotic treatments accordingly. Our tests also enable detecting carbapenemase-producing bacteria without using bacterial culture, which is faster and allows analyses by the bedside.

Finally, we are also developing wearable biosensors for diagnosing sepsis and prognosticating severe infections. This includes wearable biosensors for the continuous monitoring of lactate levels as well as approaches for diagnosing COVID-19 non-invasively.